![]() * indicates p < 0.05, and ** indicates p < 0.01. This Review provides a comprehensive overview of the neuronal heterogeneity, circuit architecture and functional roles of the external globus pallidus, with emphasis on how the latest data deviate. AMY, amygdala BG, basal ganglia PB, parabrachial nucleus RVM, rostroventral medulla S2, secondary somatosensory cortex. The most cited journal in its field, exploring psychological sciences - from clinical research to cognitive science, from imaging studies to human factors. Grey regions show parts of the ascending pain pathways depicted in FIG. Emotions (and placebo analgesia) activate circuitry involving the anterior cingulate cortex (ACC), prefrontal cortex (PFC) and periaqueductal grey (PAG) (shown in green), whereas attention activates circuitry involving projections from the superior parietal lobe (SPL) to the primary somatosensory cortex (S1) and insula (shown in blue). b | Attention and emotion alter pain via different descending modulatory systems. Nature Reviews Neuroscience is a monthly peer-reviewed review journal published by Nature Portfolio. By contrast, altering the mood state alters the perceived unpleasantness of the pain without altering the intensity of the sensation (bottom graph). They show the enormous influence of neuroimaging techniques and highlight concepts that have generated substantial interest in the past decade, such as. A | Manipulating the attentional state primarily alters the perceived intensity of the pain sensation without significantly altering the perceived unpleasantness of the pain (top graph).
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